Triptych Panel: A Saint Pope, Saint Sebastian, and the Temptation of St. Anthony

The upper panel displays a standing saint in full papal regalia, wearing a mitre and holding a patriarchal cross, positioned next to Saint Sebastian, who is dressed in mid-15th century court attire and holds a long bow. The lower panel depicts an elderly, bearded Saint Anthony the Great sprawled on the ground, beset by multiple dark-skinned demons with wings, horns, and clawed feet who pull at his hair and body. In the background of the lower scene, a small, cubic building with a cross atop it sits near a mountain cave, signifying the monk's hermitage. The work utilizes a Gothic architectural frame and gold-leaf halos for the saints, emphasizing a contrast between the orderly, static poses of the saints above and the chaotic, visceral violence of the temptations below.

The depiction of Saint Anthony's temptation draws directly from Athanasius of Alexandria's 'Life of Saint Anthony', which popularized the hagiographic tradition of the ascetic desert anchorite battling demonic manifestations of human desire and fear. The juxtaposition with Sebastian and a Pope highlights the dual medieval focus on martyrdom, ecclesiastical authority, and the personal spiritual warfare required of the monastic life.