Rust op de vlucht naar Egypte. NL-HlmNHA 1477 53009974

Mary sits on the ground cradling the infant Jesus, while Joseph is visible in the background tending to their donkey beside crumbling stone architecture. A prominent, detailed tree dominates the center of the composition, set against a vast mountainous landscape with a distant waterfall. The figures are rendered with the dynamic, muscular forms characteristic of the artist's mannerist style.

The Latin inscription elevates this biblical scene to a cosmological level, identifying the infant Christ as the 'Cæli opifex' (heavenly craftsman or Demiurge) who governs the universe and created the sun and moon. This reflects late Renaissance Neoplatonic efforts to harmonize Christian theology with the philosophical concept of a governing universal architect as found in the Hermetic and Platonic traditions.