Baglioni-Altar, Haupttafel, Szene: Kreuzabnahme

A group of mourning figures carries Christ in a burial shroud as they move toward a cave entrance on the left. Mary Magdalene reaches out to clasp Christ's hand in grief, while on the right, the Virgin Mary collapses and is supported by three women. The background features the hill of Calvary with three empty crosses under a soft, expansive sky.

This work represents the High Renaissance ideal of the 'istoria,' where complex anatomical movement is used to express profound psychological and spiritual states. It reflects the Neoplatonic effort to harmonize the physical perfection of classical antiquity—seen in the Roman sarcophagus-inspired composition—with Christian theology.