Portrait of Pope Leo X and his cousins, cardinals Giulio de' Medici and Luigi de' Rossi.

Pope Leo X sits at a red-covered table, studying an illuminated Bible with the aid of a magnifying glass. He is flanked by his cousins, Cardinals Giulio de' Medici and Luigi de' Rossi, who stand in the shadows of a dark architectural space. The painting captures the specific textures of the papal velvet robes and the intricate metalwork of a silver bell.

As the son of Lorenzo the Magnificent, Leo X was a product of the Medici household's Neoplatonic circle. This portrait illustrates the intersection of ecclesiastical authority and the humanistic scholarship championed by the Medici, who were the primary patrons of Marsilio Ficino and the Florentine Academy.