Raffaello, autoritratto con un amico, 1518-19 ca.

Raphael appears in the background with a beard and direct gaze, resting his left hand on his friend's shoulder in a gesture of intimacy. The man in the foreground is shown in profile, turning his head toward the artist while pointing with his right hand toward the viewer's space. Both figures are dressed in the sober, dark attire of the high Renaissance, characterized by voluminous sleeves and white pleated collars.

This painting is a primary example of the Renaissance concept of 'amicitia' (virtuous friendship), which Neoplatonists like Marsilio Ficino described as the union of two souls into one. It reflects the elevated status of the artist as a philosopher and gentleman within the intellectual circles of the Roman court.