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...est—if you remove even one, you] would mutilate the use of the whole. Since, therefore, all things that exist come together into the composition of the entire Universe, as if into a single Commonwealth original: "Reipublicæ", with a concatenation concatenation: a chain-like connection where things are linked together in a specific order. that is never interrupted: if even one significant thing is ignored, it is necessary that the truth of many others be obscured at the same time. Certainly, what Seneca said regarding the writings of the greatest men (Epistle 33) applies here: They must be inspected in their entirety, and handled as a whole; for they weave their work through the outlines of their own genius, from which nothing can be withdrawn without ruin. This may be said far more truly of the entire structure of Reality and Learning: that nothing can be withdrawn without ruin. And what that same author said elsewhere regarding life’s plans and the errors of those plans (Epistle 72): We fail because we all deliberate over the parts of life, but no one deliberates over the whole: this fits most appropriately with the search for Truth. Thus we wander in various ways because we deliberate over the parts of Truth; yet no one is concerned with the whole, universal, and all-encompassing Truth that connects itself on every side. Francisco Sanchez Francisco Sánchez (c. 1550–1623) was a skeptical philosopher and physician. His work "Quod Nihil Scitur" (That Nothing is Known) argued that perfect knowledge is impossible because of the interconnectedness of all things. also saw this and expressed it thus (in his book, That Nothing is Known, page 47): Such is the link between things...