Ioannis Vuieri medicarum observationum rararum Liber I

especially when the patient moves, or rises, or sits; then also, he almost or entirely loses his soul [faints] at times; when lying down, however, he breathes more freely and is refreshed. Some frequently desire food; in others, the desire to eat languishes. An aggravating movement is observed in many on the fourth or fifth day, in most on the third, in a few on individual days, yet without a manifest fever. There is no doubt that some are simultaneously feverish at times. For some, having been seized by this plague, are affected by a slow, erratic fever. Sometimes even burning, malignant, double tertian fevers have preceded; and I have seen where, in scurvy itself, not yet perfectly cured after those fevers, a very malignant quartan fever would follow; and in the very decline of the quartan, scurvy appeared again, finally [cured] with healthy counsel for diet. Thus, such fevers are often seen not to be ended by crisis so much as to produce new diseases from the weakened viscera, atrophy, and much corruption and rot of the blood, not rarely worse than the previous ones. In some, the bowels are more constricted; in others, more loose. That lividity of the legs sometimes surrounds the entire lower shins on all sides, down to the feet, with swelling, such that one might judge it to be a sign of elephantiasis; again, the legs of others are so thinned that the skin alone seems to cover the bones, usually with much heat, sometimes without it. The spots of some even resolve into scales, just as is usually seen in erysipelas; those of others remain smooth, equal, sometimes shining with a slight trace to the finger