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I. So that the perfect course of times may sometimes be anticipated, the patient and the physician are responsible.
V.
Unhealthy diseases are at least devoid of a decline: lethal ones necessarily so: dangerous ones otherwise.
VI.
Each of the four times has a beginning, a middle, and an end.
1. As in the ages of animals and the seasons of the year: so we divide the span of times in diseases for a more certain cure.
2. Thus, in the first part of the beginning, according to Galen, an inflammation requires repelling agents: at the end, it requires repelling and digestive agents together; but the former more so.
3. The same mixtures are suitable for the increase: yet repelling agents should prevail, and indeed more so in the first part than the second, and in this more than the third.
4. In the beginning of the state, both are used equally: in the middle, digestive agents are used more: at the end, purely these; yet they should be milder than those used in the decline.
VII.
The times are taken from the essence of the disease, or the matter, or the symptoms.
1. The essence of the disease is the κατασκευὴ παρὰ φύσιν unnatural constitution, which, considered in itself, is called Formal: as it acts, it is called Effective.
2. It is either an intemperance, a bad composition, or a third type known in antiquity as ἀνώνυμον nameless: by Galen it was called the solution of unity, the corruption of continuity, etc.
3. The constitution arising from the instruments (which the faculty always uses) is the first and immediate cause of the action. Therefore, in the principal definition of a disease, they are redundant primarily and by themselves.
4. The actions of nature and medicine oppose the action of the disease.
VIII.
These three times sometimes coincide, sometimes not.
1. The same disease is not absurdly said to be simultaneously in the beginning and in the increase, etc.
IX.
There is one time of disease that is particular, another that is universal.
X.
The particular time is the time of individual paroxysms.
1. This has a place not only in ophthalmia, hemicrania, and pains of the ears and joints, but it also makes fevers most remarkable.
2. Yet this is so, in that the generation of these is no more to be attributed to the gods than is Epilepsy.
XI.
The four parts of a particular time are themselves called times.