Room of the Segnatura - Disputation of the Holy Sacrament (15648102865)

The composition is divided into two realms: an upper celestial level where God the Father, Christ, and the Holy Spirit appear with saints and prophets on clouds, and a lower terrestrial level where theologians and church fathers debate around an altar. At the center, a vertical axis aligns the three persons of the Trinity with a monstrance containing the consecrated Host. Figures such as Dante and several Popes are visible among the crowd, gesturing toward the altar or engaging in deep study.

As part of the Stanza della Segnatura, this work represents the synthesis of faith and reason within the Neoplatonic framework of the Renaissance Papacy. It illustrates the hierarchy of being, showing how human discourse (theology) ascends toward divine revelation and the mystical union represented by the Eucharist.